The human RIT2 core promoter short tandem repeat predominant allele is species-specific in length: a selective advantage for human evolution?
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-017-1294-4
Abstract: Evolutionary analyses of the critical core promoter interval support a selective advantage for expanding the length of certain short tandem repeats (STRs) in humans. We recently reported genome-wide data on human core promoter STRs that… read more here.
Keywords: allele; core promoter; repeat; selective advantage ... See more keywords
Quantification of the Selective Advantage of Driver Mutations Is Dependent on the Underlying Model and Stage of Tumor Evolution
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Research"
DOI: 10.1158/0008-5472.can-21-1064
Abstract: Measuring the selective fitness advantages provided by driver mutations has the potential to facilitate a precise quantitative understanding of cancer evolution. However, accurately measuring the selective advantage of driver mutations has remained a challenge in… read more here.
Keywords: model stage; evolution; selective advantage; driver mutations ... See more keywords
Towards a Better Understanding of Cohesin Mutations in AML
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00867
Abstract: Classical driver mutations in acute myeloid leukemia (AML) typically affect regulators of cell proliferation, differentiation, and survival. The selective advantage of increased proliferation, improved survival, and reduced differentiation on leukemia progression is immediately obvious. Recent… read more here.
Keywords: selective advantage; understanding cohesin; mutations aml; cohesin mutations ... See more keywords