Design and Synthesis of Orexin 1 Receptor-Selective Agonists.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01773
Abstract: Orexins are a family of neuropeptides that regulate various physiological events, such as sleep/wakefulness as well as emotional and feeding behavior, and that act on two G-protein-coupled receptors, i.e., orexin 1 (OX1R) and orexin 2… read more here.
Keywords: design synthesis; orexin; ox1r selective; synthesis orexin ... See more keywords
Development of a selective agonist for relaxin family peptide receptor 3
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-03465-7
Abstract: Relaxin family peptides perform a variety of biological functions by activating four G protein-coupled receptors, namely RXFP1–4. Among these receptors, RXFP3 lacks a specific natural or synthetic agonist at present. A previously designed chimeric R3/I5… read more here.
Keywords: towards rxfp3; selective agonist; relaxin family; agonist ... See more keywords
Orexin 2 receptor–selective agonist danavorexton improves narcolepsy phenotype in a mouse model and in human patients
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207531119
Abstract: Significance Despite the discovery of the orexin (hypocretin) neuropeptides in 1998 and their role in narcolepsy type 1 (NT1), current pharmacotherapy addresses only the associated symptoms and not the underlying loss of orexin. Danavorexton (TAK-925)… read more here.
Keywords: orexin; danavorexton; mouse; selective agonist ... See more keywords