C2-selective alkylation of pyridines by rhodium–aluminum complexes
Sign Up to like & getrecommendations! Published in 2021 at "Tetrahedron"
DOI: 10.1016/j.tet.2021.132339
Abstract: Abstract A C2- and mono-selective alkylation of various pyridines and azines with unactivated alkenes and vinylarenes using a heterobimetallic Rh–Al catalyst is reported. The use of aliphatic alkenes exclusively affords the linear alkylation products, while… read more here.
Keywords: alkylation pyridines; rhodium aluminum; selective alkylation; alkylation ... See more keywords
para-Selective Alkylation of Sulfonylarenes by Cooperative Nickel/Aluminum Catalysis.
Sign Up to like & getrecommendations! Published in 2017 at "Organic letters"
DOI: 10.1021/acs.orglett.6b03741
Abstract: A method for the para-selective alkylation of a variety of arenesulfonamides and aromatic sulfones with 1-alkenes by cooperative nickel/aluminum catalysis has been developed. Taking advantage of the sulfornyl functionality serving as a removable ortho-directing group,… read more here.
Keywords: nickel aluminum; selective alkylation; para selective; aluminum catalysis ... See more keywords
Scandium-Catalyzed para-Selective Alkylation of Aromatic Amines with Alkenes.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b03451
Abstract: An efficient para-alkylation of primary and secondary anilines with a variety of sterically encumbered alkenes using a simple β-diketiminato scandium catalyst is reported. This protocol features 100% atom economy, excellent chemo- and regioselectivity, broad substrate… read more here.
Keywords: scandium catalyzed; selective alkylation; para selective; alkylation aromatic ... See more keywords
Visible Light-Driven C4-Selective Alkylation of Pyridinium Derivatives with Alkyl Bromides.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.0c04499
Abstract: Reported herein is a general strategy for the photochemical cross-coupling between N-amidopyridinium salts and various alkyl bro-mides under photocatalyst-free conditions, granting facile access to various C4-alkylated pyridines. This approach exploits the intri-guing photochemical activity of… read more here.
Keywords: alkylation pyridinium; selective alkylation; visible light; driven selective ... See more keywords
Rhodium(i)-catalyzed mono-selective C-H alkylation of benzenesulfonamides with terminal alkenes.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc05219d
Abstract: The Rh(i)-catalyzed ortho-alkylation of benzenesulfonamides with alkenes with the aid of an 8-aminoquinoline directing group is reported. The reaction is applicable to a variety of benzenesulfonamide derivatives and various alkenes. Curiously, unactivated 1-alkenes were more… read more here.
Keywords: alkylation benzenesulfonamides; rhodium catalyzed; selective alkylation; mono selective ... See more keywords
B(C6F5)3-Catalyzed site-selective N1-alkylation of benzotriazoles with diazoalkanes.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc03048e
Abstract: Alkylation of benzotriazoles is synthetically challenging, often leading to mixtures of N1 and N2 alkylation. Herein, metal-free catalytic site-selective N1-alkylation of benzotriazoles with diazoalkanes is described in the presence of 10 mol% of B(C6F5)3. These… read more here.
Keywords: alkylation benzotriazoles; site selective; selective alkylation; benzotriazoles diazoalkanes ... See more keywords
Visible-light-driven site-selective alkylation of the benzo core of coumarins.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc03073j
Abstract: An unprecedented, straightforward photochemical platform for efficient site-selective C-H alkylation of the C7 position of the benzocore via the cross coupling between coumarins and NHPI esters, employing Ru(II) as a photocatalyst in visible light, has… read more here.
Keywords: site selective; light driven; visible light; selective alkylation ... See more keywords
Facile and selective N-alkylation of gentamicin antibiotics via chemoenzymatic synthesis
Sign Up to like & getrecommendations! Published in 2022 at "Green Chemistry"
DOI: 10.1039/d2gc03600b
Abstract: The rise and spread of antimicrobial resistance has necessitated the development of novel antimicrobials which are effective against drug resistant pathogens. Aminoglycoside antibiotics (AGAs) remain one of our most effective classes of bactericidal drugs. However,… read more here.
Keywords: step; facile selective; synthesis; selective alkylation ... See more keywords
HFIP-promoted para-selective alkylation of anilines and phenols with tertiary alkyl bromides
Sign Up to like & getrecommendations! Published in 2023 at "Organic Chemistry Frontiers"
DOI: 10.1039/d3qo00342f
Abstract: A Hexafluoroisopropanol-promoted highly regioselective Friedel-Crafts alkylation of arenes has been developed in this study. Various arenes, including anilides, anisoles, and phenols, were compatible with the reaction, leading to the para-alkylated... read more here.
Keywords: alkylation anilines; para selective; alkylation; hfip promoted ... See more keywords
Electrochemical Site-Selective Alkylation of Azobenzenes with (Thio)Xanthenes
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27154967
Abstract: Herein, we first report an electrochemical methodology for the site-selective alkylation of azobenzenes with (thio)xanthenes in the absence of any transition metal catalyst or external oxidant. A variety of groups are compatible with this electrochemical… read more here.
Keywords: site selective; azobenzenes thio; alkylation; thio xanthenes ... See more keywords
The Use of Anhydrous Barium Hydroxide for Selective Alkylation of Dialkyloxy-tert-butyl-calix[4]arenes
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28031089
Abstract: A practical method of selective alkylation of the third hydroxyl group of disubstituted tert-butyl-calix[4]arenes using anhydrous barium hydroxide as a base was developed in this study. The use of this method in the synthesis of… read more here.
Keywords: anhydrous barium; barium hydroxide; selective alkylation; tert butyl ... See more keywords