Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3)
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DOI: 10.1021/acs.jmedchem.7b01674
Abstract: PRMT3 catalyzes the asymmetric dimethylation of arginine residues of various proteins. It is crucial for maturation of ribosomes and has been implicated in several diseases. We recently disclosed a highly potent, selective, and cell-active allosteric… read more here.
Keywords: potent selective; discovery potent; allosteric inhibitors; selective allosteric ... See more keywords