Leptin Contributes to Neuropathic Pain via Extrasynaptic NMDAR-nNOS Activation
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-02180-1
Abstract: Leptin is an adipocytokine that is primarily secreted by white adipose tissue, and it contributes to the pathogenesis of neuropathic pain in collaboration with N-methyl-D-aspartate receptors (NMDARs). Functional NMDARs are a heteromeric complex that primarily… read more here.
Keywords: ro25 6981; extrasynaptic nmdar; leptin; neuropathic pain ... See more keywords
Role of muscarinic receptors in the contraction of jejunal smooth muscle in the horse: An in vitro study.
Sign Up to like & getrecommendations! Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.07.012
Abstract: Nonselective antimuscarinic drugs are clinically useful in several pathologic conditions of horses, but, blocking all muscarinic receptor (MR) subtypes, may cause several side effects. The availability of selective antimuscarinic drugs could improve therapeutic efficacy and… read more here.
Keywords: selective antagonists; muscle; role; jejunum ... See more keywords
KD-64—A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist—Caffeine does not reduce diet-induced obesity in mice
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0229806
Abstract: The A2 adenosine receptors play an important role, among others, in the regulation of inflammatory process and glucose homeostasis in diabetes and obesity. Thus, the presented project evaluated of influence of the selective antagonist of… read more here.
Keywords: non selective; a2a; antagonist; adenosine ... See more keywords
Structural insights into the subtype-selective antagonist binding to the M2muscarinic receptor
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemical Biology"
DOI: 10.2210/pdb5yc8/pdb
Abstract: Human muscarinic receptor M2 is one of the five subtypes of muscarinic receptors belonging to the family of G-protein-coupled receptors. Muscarinic receptors are targets for multiple neurodegenerative diseases. The challenge has been designing subtype-selective ligands… read more here.
Keywords: muscarinic receptors; structural insights; receptor; subtype selective ... See more keywords