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Published in 2017 at "Research in veterinary science"
DOI: 10.1016/j.rvsc.2017.07.012
Abstract: Nonselective antimuscarinic drugs are clinically useful in several pathologic conditions of horses, but, blocking all muscarinic receptor (MR) subtypes, may cause several side effects. The availability of selective antimuscarinic drugs could improve therapeutic efficacy and…
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Keywords:
selective antagonists;
muscle;
role;
jejunum ... See more keywords
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Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.1c01636
Abstract: We herein document a large collection of 108 2-amino-4,6-disubstituted-pyrimidine derivatives as potent, structurally simple, and highly selective A1AR ligands. The most attractive ligands were confirmed as antagonists of the canonical cyclic adenosine monophosphate pathway, and…
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Keywords:
amino diarylpyrimidine;
diarylpyrimidine carbonitriles;
carbonitriles potent;
selective antagonists ... See more keywords