Alpha-synuclein oligomer-selective antibodies reduce intracellular accumulation and mitochondrial impairment in alpha-synuclein exposed astrocytes
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DOI: 10.1186/s12974-017-1018-z
Abstract: BackgroundDue to its neurotoxic properties, oligomeric alpha-synuclein (α-syn) has been suggested as an attractive target for passive immunization against Parkinson’s disease (PD). In mouse models of PD, antibody treatment has been shown to lower the… read more here.
Keywords: accumulation; selective antibodies; alpha synuclein; mitochondrial impairment ... See more keywords