Improved therapeutic index of an acidic pH-selective antibody
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2021.2024642
Abstract: ABSTRACT Although therapeutically efficacious, ipilimumab can exhibit dose-limiting toxicity that prevents maximal efficacious clinical outcomes and can lead to discontinuation of treatment. We hypothesized that an acidic pH-selective ipilimumab (pH Ipi), which preferentially and reversibly… read more here.
Keywords: selective antibody; therapeutic index; improved therapeutic; acidic selective ... See more keywords
The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Neuroinflammation"
DOI: 10.1186/s12974-018-1134-4
Abstract: BackgroundCurrently, several amyloid beta (Aβ) antibodies, including the protofibril selective antibody BAN2401, are in clinical trials. The murine version of BAN2401, mAb158, has previously been shown to lower the levels of pathogenic Aβ and prevent… read more here.
Keywords: selective antibody; accumulation astrocytes; protofibril selective; cell death ... See more keywords
Selective Antibody-Free Sensing Membranes for Picogram Tetracycline Detection
Sign Up to like & getrecommendations! Published in 2022 at "Biosensors"
DOI: 10.3390/bios13010071
Abstract: As an antibody-free sensing membrane for the detection of the antibiotic tetracycline (TC), a liquid PVC membrane doped with the ion-pair tetracycline/θ-shaped anion [3,3′-Co(1,2-C2B9H11)2]− ([o-COSAN]−) was formulated and deposited on a SWCNT modified gold microelectrode.… read more here.
Keywords: free sensing; antibody free; selective antibody; detection ... See more keywords