Multiple functions of CALCOCO family proteins in selective autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30836
Abstract: Selective autophagy is the lysosomal degradation of specific intracellular components sequestered into autophagosomes, late endosomes, or lysosomes through the activity of selective autophagy receptors. CALCOCO family proteins are the newly found selective autophagy receptors, which… read more here.
Keywords: proteins selective; selective autophagy; family proteins; calcoco family ... See more keywords
Silica Nanoparticles Trigger Chaperone HSPB8-Assisted Selective Autophagy via TFEB Activation in Hepatocytes.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202204310
Abstract: Silica nanoparticles (SiNPs) are one of the most common inorganic nanomaterials. Autophagy is the predominant biological response to nanoparticles and transcription factor EB (TFEB) is a master regulator of the autophagy-lysosome pathway. Previous studies show… read more here.
Keywords: tfeb; assisted selective; silica nanoparticles; hspb8 ... See more keywords
Selective autophagy controls innate immune response through a TAK1/TAB2/SH3PX1 axis.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.1016/j.celrep.2021.110286
Abstract: Selective autophagy is a catabolic route that turns over specific cellular material for degradation by lysosomes, and whose role in the regulation of innate immunity is largely unexplored. Here, we show that the apical kinase… read more here.
Keywords: tak1 tab2; tab2 sh3px1; selective autophagy; autophagy ... See more keywords
Recruitment and Activation of the ULK1/Atg1 Kinase Complex in Selective Autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Biology"
DOI: 10.1016/j.jmb.2019.07.027
Abstract: Autophagy is a major cellular degradation pathway, which mediates the delivery of cytoplasmic cargo material into lysosomes. This is achieved by the specific sequestration of the cargo within double-membrane vesicles, the autophagosomes, which form de… read more here.
Keywords: ulk1 atg1; selective autophagy; kinase complex; atg1 kinase ... See more keywords
Selective Autophagy Receptors in Antiviral Defense.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in microbiology"
DOI: 10.1016/j.tim.2021.02.006
Abstract: Autophagy ensures the degradation of cytosolic substrates by the lysosomal pathway. Cargoes destined to be eliminated are confined within double-membrane vesicles called autophagosomes, prior to fusion with endolysosomal vacuoles. Autophagy receptors selectively interact with cargoes… read more here.
Keywords: selective autophagy; antiviral defense; autophagy; autophagy receptors ... See more keywords
Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06115-2
Abstract: Niemann–Pick type C disease is a fatal, progressive neurodegenerative disorder caused by loss-of-function mutations in NPC1, a multipass transmembrane glycoprotein essential for intracellular lipid trafficking. We sought to define the cellular machinery controlling degradation of… read more here.
Keywords: dependent erad; selective autophagy; march6 dependent; i1061t npc1 ... See more keywords
Phosphorylation regulates the binding of autophagy receptors to FIP200 Claw domain for selective autophagy initiation
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21874-1
Abstract: The ULK complex initiates the autophagosome formation, and has recently been implicated in selective autophagy by interacting with autophagy receptors through its FIP200 subunit. However, the structural mechanism underlying the interactions of autophagy receptors with… read more here.
Keywords: fip200 claw; receptors fip200; selective autophagy; autophagy receptors ... See more keywords
Selective autophagy: adding precision in plant immunity
Sign Up to like & getrecommendations! Published in 2022 at "Essays in Biochemistry"
DOI: 10.1042/ebc20210063
Abstract: Abstract Plant immunity is antagonized by pathogenic effectors during interactions with bacteria, viruses or oomycetes. These effectors target core plant processes to promote infection. One such core plant process is autophagy, a conserved proteolytic pathway… read more here.
Keywords: autophagy adding; selective autophagy; plant immunity; autophagy ... See more keywords
Chaperone-assisted selective autophagy targets filovirus VP40 as a client and restricts egress of virus particles.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2210690120
Abstract: The filovirus VP40 protein directs virion egress, which is regulated either positively or negatively by select VP40-host interactions. We demonstrate that host BAG3 and HSP70 recognize VP40 as a client and inhibit the egress of… read more here.
Keywords: chaperone assisted; assisted selective; vp40 client; filovirus vp40 ... See more keywords
Ubiquitin-coated nanodiamonds bind to autophagy receptors for entry into the selective autophagy pathway
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2016.1254864
Abstract: ABSTRACT Selective macroautophagy/autophagy plays a pivotal role in the processing of foreign pathogens and cellular components to maintain homeostasis in human cells. To date, numerous studies have demonstrated the uptake of nanoparticles by cells, but… read more here.
Keywords: selective autophagy; autophagy pathway; bind autophagy; autophagy ... See more keywords
Crosstalk between the innate immune system and selective autophagy in hepatitis B virus infection
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2059747
Abstract: ABSTRACT Although the involvement of macroautophagy/autophagy in hepatitis B virus (HBV) infection has become clearer recently, whether selective autophagy plays an important role in suppressing HBV remains uncertain. We recently found that LGALS9 (galectin 9)… read more here.
Keywords: autophagy hepatitis; hbv; infection; selective autophagy ... See more keywords