Discovery and synthesis of the first selective BAG domain modulator of BAG3 as an attractive candidate for the development of a new class of chemotherapeutics.
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DOI: 10.1039/c8cc03399d
Abstract: BAG3 protein has emerged as a key regulator of important cellular processes and its expression is increased in some tumor types; however, despite its potential value for future chemotherapeutics, no selective BAG3 modulators have been… read more here.
Keywords: first selective; discovery synthesis; bag3; synthesis first ... See more keywords