Synthesis, computational predictions of selective bioactive nicotinamide derivatives and in vitro biological evaluations
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.06.048
Abstract: Abstract A series of nicotinamide derivatives were designed and studied in silico molecular docking predictions against inflammatory responsible enzymes (cyclooxygenase-1(1PGG) and cyclooxygenase-2 (4-COX)). The well-predicted compounds were synthesized, characterized by the spectroscopic techniques namely, Proton… read more here.
Keywords: predictions selective; nicotinamide derivatives; synthesis computational; vitro biological ... See more keywords
Rational Design of Selective and Bioactive Inhibitors of the Mycobacterium tuberculosis Proteasome.
Sign Up to like & getrecommendations! Published in 2017 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.6b00172
Abstract: The 20S core particle of the proteasome in Mycobacterium tuberculosis (Mtb) is a promising, yet unconventional, drug target. This multimeric peptidase is not essential, yet degrades proteins that have become damaged and toxic via reactions… read more here.
Keywords: bioactive inhibitors; design selective; rational design; tuberculosis ... See more keywords