Discovery of potent and selective BRD4 inhibitors capable of blocking TLR3-induced acute airway inflammation.
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DOI: 10.1016/j.ejmech.2018.04.006
Abstract: A series of diverse small molecules have been designed and synthesized through structure-based drug design by taking advantage of fragment merging and elaboration approaches. Compounds ZL0420 (28) and ZL0454 (35) were identified as potent and… read more here.
Keywords: potent selective; brd4 inhibitors; airway inflammation; brd4 ... See more keywords