Strategies to develop selective CB2 receptor agonists from indole carboxamide synthetic cannabinoids.
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DOI: 10.1016/j.ejmech.2019.07.036
Abstract: Activation of the CB2 receptor is an attractive therapeutic strategy for the treatment of a wide range of inflammatory diseases. However, receptor subtype selectivity is necessary in order to circumvent the psychoactive effects associated with… read more here.
Keywords: selective cb2; synthetic cannabinoids; cb2 receptor; develop selective ... See more keywords
A computational prospective on isoform-selective CB2 inhibitors
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DOI: 10.1039/d1nj02296b
Abstract: The strategy of enlarging the molecular size, increasing hydrogen bond interactions with the key residues of CB2, and furthering geometric distribution of hydrophobic groups would improve the selectivity towards CB2 receptor. read more here.
Keywords: prospective isoform; computational prospective; isoform selective; chemistry ... See more keywords
Rational drug design of CB2 receptor ligands: from 2012 to 2021
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DOI: 10.1039/d2ra05661e
Abstract: Cannabinoid receptors belong to the large family of G-protein-coupled receptors, which can be divided into two receptor types, cannabinoid receptor type-1 (CB1) and cannabinoid receptor type-2 (CB2). Marinol, Cesamet and Sativex are marketed CB1 drugs… read more here.
Keywords: selective cb2; cb2; rational drug; drug design ... See more keywords
The Selective CB2 Agonist COR167 Reduced Symptoms in a Mice Model of Trauma-Induced Peripheral Neuropathy through HDAC-1 Inhibition
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DOI: 10.3390/biomedicines11061546
Abstract: Neuropathic pain is a chronic disabling condition with a 7–10% of prevalence in the general population that is largely undertreated. Available analgesic therapies are poorly effective and are often accompanied by numerous side effects. Growing… read more here.
Keywords: cor167; selective cb2; neuropathic pain; pain ... See more keywords