Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective
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DOI: 10.3389/fchem.2025.1582515
Abstract: Studying the selectivity mechanism of inhibitors towards highly similar isoforms is an important task in the development of new drugs, which are designed to avoid the undesired side effects in vivo. CDC-like kinase isoforms (CLKs)… read more here.
Keywords: selective clk1; clk1 inhibition; computational perspective; clk1 ... See more keywords