Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound
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DOI: 10.1021/acsmedchemlett.5c00215
Abstract: Herein we describe our continuing work on the K2P family of potassium ion channels with the chemical optimization of a selective and CNS penetrant series of TREK inhibitors, culminating in the discovery of ONO-TR-772 (VU6018042).… read more here.
Keywords: selective cns; ono 772; trek; cns penetrant ... See more keywords
Abstract LB240: Preclinical evaluation of ABSK112, a selective and CNS-penetrant compound with strong HER2 inhibitory activity for treating HER2-driven solid tumors
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DOI: 10.1158/1538-7445.am2025-lb240
Abstract: HER2+ cancers, driven by the overexpression or amplification of the HER2 oncogene, are prevalent in various malignancies, including breast, gastric, and lung cancers. These tumors are often associated with a heightened risk of brain metastases.… read more here.
Keywords: selective cns; cns penetrant; her2; her2 driven ... See more keywords