Efficacy and safety of selective COX-2 inhibitors for pain management after third molar removal: a meta-analysis of randomized clinical trials
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02910-3
Abstract: Objectives To compare selective COX-2 inhibitors with ibuprofen in terms of analgesia, rescue medication consumption, and adverse effects after impacted third molar removal. Materials and methods Electronic databases were searched. Single dose, double-blind, randomized, and… read more here.
Keywords: selective cox; cox inhibitors; third molar; molar removal ... See more keywords
Development of a selective COX-2 inhibitor: from synthesis to enhanced efficacy via nano-formulation
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DOI: 10.1039/d4ra06295g
Abstract: Non-steroidal anti-inflammatory drugs NSAIDs are widely used for managing various conditions including pain, inflammation, arthritis and many musculoskeletal disorders. NSAIDs exert their biological effects by inhibiting the cyclooxygenase (COX) enzyme, which has two main isoforms… read more here.
Keywords: cox; drug; anti inflammatory; selective cox ... See more keywords
Evaluation of the Genotoxic Potential of the Selective COX-2 Inhibitor Enflicoxib in a Battery of in vitro and in vivo Genotoxicity Assays
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DOI: 10.1055/a-1727-5733
Abstract: Aim Enflicoxib, a selective COX-2 inhibitor approved for the treatment of pain and inflammation associated with osteoarthritis in dogs (Daxocox ® [Ecuphar/Animalcare Group]) was assessed for its genotoxic potential in a battery of in vitro… read more here.
Keywords: vitro; genotoxic potential; vivo; battery vitro ... See more keywords
Docking-based 3D-QSAR (CoMFA, CoMFA-RG, CoMSIA) study on hydroquinoline and thiazinan-4-one derivatives as selective COX-2 inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2018.1502687
Abstract: Abstract A series of 26 selective COX-2 inhibitors which reported previously by our laboratory was selected to generate three-dimensional quantitative structure activity relationship (3D-QSAR) model. Active conformation of each molecule was predicted by docking studies… read more here.
Keywords: comfa comfa; selective cox; comfa; cox inhibitors ... See more keywords
Selective COX-2 inhibitors as anticancer agents: a patent review (2014-2018)
Sign Up to like & getrecommendations! Published in 2019 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2019.1623880
Abstract: ABSTRACT Introduction: COX-2 is a key enzyme in the process of prostaglandins (PGs) synthesis. The products of this enzyme could play a major role as the mediators of the inflammatory response and some other medical… read more here.
Keywords: selective cox; anticancer agents; cox inhibitors; cox ... See more keywords
Non-steroidal anti-inflammatory drugs and the risk of out-of-hospital cardiac arrest: a case–control study
Sign Up to like & getrecommendations! Published in 2019 at "Europace"
DOI: 10.1093/europace/euy180
Abstract: Abstract Aims Non-steroidal anti-inflammatory drugs (NSAIDs), particularly selective COX-2 inhibitors, are associated with an increased risk of cardiovascular adverse events. However, the association between these drugs and out-of-hospital cardiac arrest with electrocardiogram-documented ventricular tachycardia/ventricular fibrillation… read more here.
Keywords: selective cox; cox inhibitors; study; case ... See more keywords
Selective cyclooxygenase inhibition by SC-560 improves hepatopulmonary syndrome in cirrhotic rats
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DOI: 10.1371/journal.pone.0179809
Abstract: Objective Hepatopulmonary syndrome (HPS) is characterized by hypoxia in patients with chronic liver disease. The mechanism of HPS includes pulmonary vasodilatation, inflammation, and angiogenesis. Prostaglandins synthesized by cyclooxygenases (COX) participate in vascular responsiveness, inflammation and… read more here.
Keywords: hepatopulmonary syndrome; selective cox; inhibition; inflammation ... See more keywords
Pyrimidine Derivatives as Selective COX-2 Inhibitors with Anti-Inflammatory and Antioxidant Properties
Sign Up to like & getrecommendations! Published in 2024 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms252011011
Abstract: Pyrimidine derivatives exhibit a wide range of biological activities, including anti-inflammatory properties. The aim of this study was to investigate the effects of tested pyrimidine derivatives on the activity of cyclooxygenase isoenzymes (COX-1 and COX-2),… read more here.
Keywords: pyrimidine derivatives; derivatives selective; antioxidant properties; anti inflammatory ... See more keywords