Design, synthesis, and biological evaluation of new 1,4‐diarylazetidin‐2‐one derivatives (β‐lactams) as selective cyclooxygenase‐2 inhibitors
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DOI: 10.1002/ardp.201900293
Abstract: A new series of 1,4‐diarylazetidin‐2‐one derivatives (β‐lactams) were designed and synthesized to evaluate their biological activities as selective cyclooxygenase‐2 (COX‐2) inhibitors. In vitro COX‐1 and COX‐2 inhibition studies showed that all compounds were selective inhibitors… read more here.
Keywords: one derivatives; new diarylazetidin; selective cyclooxygenase; derivatives lactams ... See more keywords
Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold.
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DOI: 10.1016/j.bioorg.2019.102964
Abstract: Novel candidates of thiazolo[4,5-d]pyrimidines (9a-l) were synthesized and their structures were elucidated by spectral and elemental analyses. All the novel derivatives were screened for their cyclooxygenase inhibitory effect, anti-inflammatory activity and ulcerogenic liability. All the… read more here.
Keywords: anti inflammatory; ulcerogenic liability; inhibition; inflammatory activity ... See more keywords
New selective cyclooxygenase-2 inhibitors from cyclocoumarol: Synthesis, characterization, biological evaluation and molecular modeling.
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DOI: 10.1016/j.ejmech.2018.01.054
Abstract: In this work, a serie of cyclocoumarol derivatives was designed, synthesized, characterized and studied for their potentialities as selective inhibitors of COX-2. All target compounds have been screened for their anti-inflammatory activity by the assay… read more here.
Keywords: cyclooxygenase inhibitors; new selective; selective cyclooxygenase; inhibitors cyclocoumarol ... See more keywords