Selective cytotoxicity of ent‐kaurene diterpenoids isolated from Baccharis lateralis and Baccharis retusa (Asteraceae)
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DOI: 10.1002/ardp.202200083
Abstract: This study presents the cytotoxic activity evaluation of the natural diterpenes ent‐kaurenoic acid (1) and its 15β‐hydroxy (2), 15β‐senecioyloxy (3), and 15β‐tiglinoyloxy (4) derivatives, isolated from Brazilian native plants, Baccharis retusa and B. lateralis (Asteraceae).… read more here.
Keywords: baccharis; baccharis retusa; cytotoxicity ent; selective cytotoxicity ... See more keywords
Selective cytotoxicity of a novel immunotoxin based on pulchellin A chain for cells expressing HIV envelope
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DOI: 10.1038/s41598-017-08037-3
Abstract: Immunotoxins (ITs), which consist of antibodies conjugated to toxins, have been proposed as a treatment for cancer and chronic infections. To develop and improve the ITs, different toxins such as ricin, have been used, aiming… read more here.
Keywords: selective cytotoxicity; pulchellin; novel immunotoxin; immunotoxin based ... See more keywords
Selective Cytotoxicity of Medical Cannabis (Cannabis sativa L.) Extracts Across the Whole Vegetation Cycle Under Various Hydroponic and Nutritional Treatments.
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DOI: 10.1089/can.2022.0243
Abstract: Introduction: The use of Cannabis sativa L. in health care requires stringent care for the optimal production of the bioactive compounds. However, plant phenotypes and the content of secondary metabolites, such as phytocannabinoids, are strongly… read more here.
Keywords: cannabis sativa; cell; cytotoxicity; medical cannabis ... See more keywords
Selective cytotoxicity of the anti-diabetic drug, metformin, in glucose-deprived chicken DT40 cells
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DOI: 10.1371/journal.pone.0185141
Abstract: Metformin is a biguanide drug that is widely used in the treatment of diabetes. Epidemiological studies have indicated that metformin exhibits anti-cancer activity. However, the molecular mechanisms underlying this activity currently remain unclear. We hypothesized… read more here.
Keywords: chicken dt40; depleted conditions; selective cytotoxicity; metformin glucose ... See more keywords
Selective Cytotoxicity of Complexes with N,N,N-Donor Dipodal Ligand in Tumor Cells
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DOI: 10.3390/ijms22041802
Abstract: The present article demonstrates selective cytotoxicity against cancer cells of the complexes [Co(LD)2]I2∙CH3OH (1), [CoLD(NCS)2] (2) and [VOLD(NCS)2]∙C6H5CH3 (3) containing the dipodal tridentate ligand LD = N,N-bis(3,5-dimethylpyrazol-1-ylmethyl)amine), formed in situ. All tested complexes expressed greater… read more here.
Keywords: selective cytotoxicity; cytotoxicity complexes; complexes donor; cancer cells ... See more keywords