Synthesis, Characterization, and Selective Delivery of DARPin-Gold Nanoparticle Conjugates to Cancer Cells.
Sign Up to like & getrecommendations! Published in 2017 at "Bioconjugate chemistry"
DOI: 10.1021/acs.bioconjchem.7b00410
Abstract: We demonstrate that the designed ankyrin repeat protein (DARPin)_9-29, which specifically targets human epidermal growth factor receptor 2 (HER 2), binds tightly to gold nanoparticles (GNPs). Binding of the protein strongly increases the colloidal stability… read more here.
Keywords: selective delivery; gold; cancer cells; cancer ... See more keywords
Customized Reversible Stapling for Selective Delivery of Bioactive Peptides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c10949
Abstract: We have developed a new concept for reversible peptide stapling that involves macrocyclization between two amino groups and decyclization promoted via dual 1,4-elimination. Depending on the trigger moiety, this strategy could be employed to selectively… read more here.
Keywords: selective delivery; reversible stapling; customized reversible; peptide ... See more keywords
Suppression of osteoclast multinucleation via a posttranscriptional regulation–based spatiotemporally selective delivery system
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abn3333
Abstract: Redundancy of multinucleated mature osteoclasts, which results from the excessive fusion of mononucleated preosteoclasts (pOCs), leads to osteolytic diseases such as osteoporosis. Unfortunately, the currently available clinical drugs completely inhibit osteoclasts, thus interfering with normal… read more here.
Keywords: poc; selective delivery; delivery system; spatiotemporally selective ... See more keywords
Stage-Specific and Selective Delivery of Caged Azidosugars into the Intracellular Parasite Toxoplasma gondii by Using an Esterase-Ester Pair Technique
Sign Up to like & getrecommendations! Published in 2019 at "mSphere"
DOI: 10.1128/msphere.00142-19
Abstract: Selective delivery of small molecules into intracellular parasites is particularly problematic due to the presence of multiple membranes and surrounding host cells. We have devised a method that can deliver caged molecules into an intracellular… read more here.
Keywords: toxoplasma gondii; selective delivery; intracellular parasite; stage specific ... See more keywords
Abstract 4673: Selective delivery of tumor specific antigen to dendritic cells by mannose-labeled PLGA nanoparticles to induce immune response for cancer immunotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4673
Abstract: Objective: To overcome limitation of ex vivo manipulation against dendritic cells (DC) vaccines, we developed mannose-labeled poly(d,l-lactide-co-glycolide) nanoparticles (MN-PLGA-NPs). The MN-PLGA-NPs enabled selective delivery of tumor-specific antigen to mannose receptor overexpressed DCs without ex vivo… read more here.
Keywords: plga nps; cancer; plga; selective delivery ... See more keywords
Selective delivery of clinically approved tubulin binding agents through covalent conjugation to an active targeting moiety.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220401105929
Abstract: The efficacy and tolerability of tubulin binding agents are hampered by their low specificity for cancer cells, like most clinically used anticancer agents. To improve specificity, tubulin binding agents have been covalently conjugated to agents… read more here.
Keywords: clinically approved; delivery clinically; tubulin binding; selective delivery ... See more keywords
CSPG4: A Target for Selective Delivery of Human Cytolytic Fusion Proteins and TRAIL
Sign Up to like & getrecommendations! Published in 2017 at "Biomedicines"
DOI: 10.3390/biomedicines5030037
Abstract: Chondroitin-sulfate proteoglycan 4 (CSPG4) is a transmembrane glycoprotein overexpressed on malignant cells in several cancer types with only limited expression on normal cells. CSPG4 is implicated in several signaling pathways believed to drive cancer progression,… read more here.
Keywords: fusion proteins; cspg4; target; cancer ... See more keywords
Clostridium botulinum C3 Toxin for Selective Delivery of Cargo into Dendritic Cells and Macrophages
Sign Up to like & getrecommendations! Published in 2022 at "Toxins"
DOI: 10.3390/toxins14100711
Abstract: The protein toxin C3bot from Clostridium botulinum is a mono-ADP-ribosyltransferase that selectively intoxicates monocyte-derived cells such as macrophages, osteoclasts, and dendritic cells (DCs) by cytosolic modification of Rho-A, -B, and -C. Here, we investigated the… read more here.
Keywords: cargo; clostridium botulinum; c3bote174q; selective delivery ... See more keywords