Electrochemical-Oxidation-Promoted Direct N-ortho-Selective Difluoromethylation of Heterocyclic N-Oxides.
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DOI: 10.1021/acs.orglett.1c04241
Abstract: An efficient and green electrochemical N-ortho-selective difluoromethylation method of various quinoline and isoquinoline N-oxides has been developed. In this method, sodium difluoromethanesulfinate (HCF2SO2Na) was used as the source of the difluoromethyl moiety, and various N-ortho-selective… read more here.
Keywords: selective difluoromethylation; electrochemical oxidation; oxidation promoted; ortho selective ... See more keywords
meta-Selective C–H difluoromethylation of various arenes with a versatile ruthenium catalyst
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DOI: 10.1039/c7qo00449d
Abstract: A ruthenium-enabled meta-selective C–H difluoromethylation of arenes has been developed. Various arenes bearing pyridyl, pyrazolyl, imidazolyl, or pyrimidyl directing groups, or removable oxazoline directing groups, were tolerated in this meta-selective C–H difluoromethylation, affording the difluoromethylated… read more here.
Keywords: ruthenium; difluoromethylation various; selective difluoromethylation; various arenes ... See more keywords
Pd-Catalyzed para-selective C-H difluoromethylation of aromatic carbonyls.
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DOI: 10.1039/c8cc09129c
Abstract: A novel palladium catalyzed highly para-selective C-H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields.… read more here.
Keywords: para selective; selective difluoromethylation; aromatic carbonyls; catalyzed para ... See more keywords
Synthesis of Difluoromethyl-Substituted Quinazolines through Selective Difluoromethylation
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DOI: 10.1055/a-1375-3538
Abstract: A highly selective difluoromethylation of quinazolines has been achieved by using commercially available ethyl bromodifluoroacetate as difluorocarbene precursor, providing the corresponding difluoromethyl substituted quinazoline derivatives with up to 83% yield. read more here.
Keywords: synthesis difluoromethyl; difluoromethyl substituted; substituted quinazolines; selective difluoromethylation ... See more keywords