Dopamine compartmentalization, selective dopaminergic vulnerabilities in Parkinson's disease and therapeutic opportunities
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.707
Abstract: Progressive depletion of selected dopamine neurons is central to much Parkinson's disease (PD) disability. Although symptomatic treatments can ameliorate the disabilities that this neuronal depletion causes, no current strategy is documented to slow these losses.… read more here.
Keywords: selective dopaminergic; compartmentalization; compartmentalization selective; parkinson disease ... See more keywords
Selective dopaminergic neurotoxicity of three heterocyclic amine subclasses in primary rat midbrain neurons
Sign Up to like & getrecommendations! Published in 2018 at "Neurotoxicology"
DOI: 10.1016/j.neuro.2018.01.009
Abstract: HighlightsHCAs produce selective loss of dopamine neurons in primary midbrain cultures.The threshold dose for selective neurotoxicity is HCA‐dependent.HCAs generally elicit selective dopaminergic neurite retraction.MeIQ and harmane increases oxidative damage in dopamine neurons. ABSTRACT Heterocyclic amines… read more here.
Keywords: selective dopaminergic; midbrain; dopaminergic neurotoxicity; neurotoxicity ... See more keywords