Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors.
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DOI: 10.1016/j.ejmech.2020.113019
Abstract: Lung cancer is the leading cause of cancer deaths. It has been demonstrated that epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) are efficacious in patients with EGFR mutation-positive non-small cell lung cancer (NSCLC). In… read more here.
Keywords: selective egfrl858r; pyrimidine derivatives; diaryl pyrimidine; egfrl858r t790m ... See more keywords