2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors.
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DOI: 10.1021/acsmedchemlett.7b00091
Abstract: A series of 2-aminopyrimidine derivatives were designed and synthesized as highly selective FGFR4 inhibitors. One of the most promising compounds 2n tightly bound FGFR4 with a Kd value of 3.3 nM and potently inhibited its… read more here.
Keywords: new selective; aminopyrimidine derivatives; fgfr4 inhibitors; derivatives new ... See more keywords