Evidence for opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25435-4
Abstract: TRP channel-associated factor 1/2 (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in multiple human tissues. Understanding their significance has been complicated given the locus spans a gap-ridden region with complex segmental duplications in GRCh38.… read more here.
Keywords: selective forces; forces operating; opposing selective; evidence opposing ... See more keywords
Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders
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DOI: 10.1038/s41598-017-06440-4
Abstract: In addition to high intelligence, humans evolved specialized social-cognitive skills, which are specifically affected in children with autism spectrum disorder (ASD). Genes affected in ASD represent suitable candidates to study the evolution of human social… read more here.
Keywords: selective forces; genetic diversity; distinct selective; introgression ... See more keywords
Glue Genes Are Subjected to Diverse Selective Forces during Drosophila Development
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DOI: 10.1093/gbe/evab248
Abstract: Abstract Molecular evolutionary studies usually focus on genes with clear roles in adult fitness or on developmental genes expressed at multiple time points during the life of the organism. Here, we examine the evolutionary dynamics… read more here.
Keywords: subjected diverse; selective forces; genes subjected; diverse selective ... See more keywords