Recent advances in site-selective functionalization of carbohydrates mediated by organocatalysts.
Sign Up to like & getrecommendations! Published in 2019 at "Carbohydrate research"
DOI: 10.1016/j.carres.2018.11.012
Abstract: As one of the four fundamental building blocks of life, carbohydrates assume varied and expansive roles in biological contexts. More in-depth understanding of carbohydrates and their interactions, however, is often restricted by our inability to… read more here.
Keywords: selective functionalization; site selective; site; functionalization carbohydrates ... See more keywords
Exploring the molecular basis for selective C–H functionalization in plant P450s
Sign Up to like & getrecommendations! Published in 2020 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2020.05.001
Abstract: Highly prevalent in nature, cytochrome P450 enzymes are powerful biocatalysts for selective C–H functionalization [1]. These heme-containing enzymes activate inert C–H bonds within complex molecules for a plethora of transformations with exquisite regio-, chemoand stereoselectivity.… read more here.
Keywords: plant; selective functionalization; molecular basis; p450s ... See more keywords
Multiplexed Monitoring of Neurochemicals via Electrografting-Enabled Site-Selective Functionalization of Aptamers on Field-Effect Transistors.
Sign Up to like & getrecommendations! Published in 2022 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.1c05531
Abstract: Neurochemical corelease has received much attention in understanding brain activity and cognition. Despite many attempts, the multiplexed monitoring of coreleased neurochemicals with spatiotemporal precision and minimal crosstalk using existing methods remains challenging. Here, we report… read more here.
Keywords: serotonin; site selective; multiplexed monitoring; dopamine ... See more keywords
Site-Selective Functionalization of Hydroxyl Groups in Carbohydrate Derivatives.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical reviews"
DOI: 10.1021/acs.chemrev.8b00442
Abstract: Methods for site-selective transformations of hydroxyl groups in carbohydrate derivatives are reviewed. The construction of oligosaccharides of defined connectivity hinges on such transformations, which are also needed for the preparation of modified or non-natural sugar… read more here.
Keywords: selective functionalization; site selective; hydroxyl groups; carbohydrate derivatives ... See more keywords
Site-Selective Functionalization of Unactivated Allylic C–H Bonds via Direct Deprotonation with KTMP: Application to the Formal Total Synthesis of (+)-Artemisinin from Amorphadiene
Sign Up to like & getrecommendations! Published in 2023 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c04145
Abstract: The site-selective functionalization of unactivated allylic C–H bonds via direct deprotonation using KTMP is described. The conversion of amorphadiene to artemisinic alcohol via a simple, highly regioselective deprotonation over 4 other possible allylic sites is… read more here.
Keywords: functionalization unactivated; site selective; allylic bonds; selective functionalization ... See more keywords
Delineating Physical Organic Parameters in Site-Selective C–H Functionalization of Indoles
Sign Up to like & getrecommendations! Published in 2018 at "ACS Central Science"
DOI: 10.1021/acscentsci.8b00264
Abstract: Site-selective C–H functionalization is a great challenge in homogeneous transition-metal catalysis. Herein, we present a physical organic approach to delineate the origin of regioselective amidation of N-acylindoles through Ir(III) catalysis. Bulkiness of N-directing groups of… read more here.
Keywords: selective functionalization; site selective; physical organic; delineating physical ... See more keywords
Conformational Flexibility as a Tool for Enabling Site-Selective Functionalization of Unactivated sp3 C–O Bonds in Cyclic Acetals
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c04513
Abstract: A dual catalytic manifold that enables site-selective functionalization of unactivated sp3 C–O bonds in cyclic acetals with aryl and alkyl halides is reported. The reaction is triggered by an appropriate σ*–p orbital overlap prior to… read more here.
Keywords: functionalization unactivated; unactivated sp3; site selective; sp3 bonds ... See more keywords
Chirality-Selective Functionalization of Semiconducting Carbon Nanotubes with a Reactivity-Switchable Molecule.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.7b05906
Abstract: Chirality-selective functionalization of semiconducting single-walled carbon nanotubes (SWCNTs) has been a difficult synthetic goal for more than a decade. Here we describe an on-demand covalent chemistry to address this intriguing challenge. Our approach involves the… read more here.
Keywords: functionalization semiconducting; carbon; chirality; selective functionalization ... See more keywords
Site-selective functionalization of remote aliphatic C–H bonds via C–H metallation
Sign Up to like & getrecommendations! Published in 2020 at "Chemical Science"
DOI: 10.1039/d0sc05944g
Abstract: Directing group assistance provided a paradigm for controlling site-selectivity in transition metal-catalyzed C–H functionalization reactions. However, the kinetically and thermodynamically favored formation of 5-membered metallacycles has greatly hampered the selective activation of remote C(sp3)–H bonds… read more here.
Keywords: via metallation; selective functionalization; functionalization remote; bonds via ... See more keywords
Site-selective functionalization of in-plane nanoelectrode-antennas.
Sign Up to like & getrecommendations! Published in 2023 at "Nanoscale"
DOI: 10.1039/d2nr06343c
Abstract: Stacked organic optoelectronic devices make use of electrode materials with different work functions, leading to efficient large area light emission. In contrast, lateral electrode arrangements offer the possibility to be shaped as resonant optical antennas,… read more here.
Keywords: selective functionalization; laterally arranged; site selective; functionalization plane ... See more keywords
Recent Opportunities and Challenges in Selective C-H Functionalization of Methyl Azaarenes: a Highlight from 2010 to 2020 Literatures.
Sign Up to like & getrecommendations! Published in 2021 at "Current organic synthesis"
DOI: 10.2174/1566524021666210614141628
Abstract: Azaarenes are unique scaffolds frequently found in pharmaceuticals. Herein, we have summarized the recent synthetic available methods in C-H functionalization of methylazaarenes from 2010 to 2020. Multiple approaches involving halogenation and alkylation via different methods,… read more here.
Keywords: 2010 2020; challenges selective; selective functionalization; opportunities challenges ... See more keywords