Indazole-6-phenylcyclopropylcarboxylic Acids as Selective GPR120 Agonists with in Vivo Efficacy.
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DOI: 10.1021/acs.jmedchem.7b00210
Abstract: GPR120 agonists have therapeutic potential for the treatment of diabetes, but few selective agonists have been reported. We identified an indazole-6-phenylcyclopropylcarboxylic acid series of GPR120 agonists and conducted SAR studies to optimize GPR120 potency. Furthermore,… read more here.
Keywords: acids selective; indazole phenylcyclopropylcarboxylic; selective gpr120; gpr120 agonists ... See more keywords