Structural basis for the selective incorporation of an artificial nucleotide opposite a DNA adduct by a DNA polymerase.
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DOI: 10.1039/c7cc07173f
Abstract: The possibility to sequence cytotoxic O6-alkylG DNA adducts would greatly benefit research. Recently we reported a benzimidazole-derived nucleotide that is selectively incorporated opposite the damaged site by a mutated DNA polymerase. Here we provide the… read more here.
Keywords: structural basis; dna; dna polymerase; basis selective ... See more keywords