Continuing Impacts of Selective Inhibition on Bacterial and Fungal Communities in an Agricultural Soil
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Ecology"
DOI: 10.1007/s00248-019-01364-0
Abstract: Selective inhibition (SI) has been routinely used to differentiate the contributions of bacteria and fungi to soil ecological processes. SI experiments typically measured rapid responses within hours since the addition of inhibitor, but the long-term… read more here.
Keywords: inhibition; agricultural soil; selective inhibition; bacterial fungal ... See more keywords
New insights into the selective inhibition of the β-carbonic anhydrases of pathogenic bacteria Burkholderia pseudomallei and Francisella tularensis: a proteochemometrics study
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Diversity"
DOI: 10.1007/s11030-018-9869-5
Abstract: Nowadays, antibiotic resistance has turned into one of the most important worldwide health problems. Biological end point of critical enzymes induced by potent inhibitors is recently being considered as a highly effective and popular strategy… read more here.
Keywords: carbonic anhydrase; carbonic anhydrases; selective inhibition; insights selective ... See more keywords
Experimental Investigations and Parametric Optimization of Process Parameters on Shrinkage Characteristics of Selective Inhibition Sintered High Density Polyethylene Parts
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Techniques"
DOI: 10.1007/s40799-018-0286-6
Abstract: Fabrication of functional prototypes from computer-aided design data through joining polymer powders particles is accomplished using selective inhibition sintering (SIS) process. The dimensional accuracy of sintered specimens in SIS process is significantly affected for the… read more here.
Keywords: sis; parameters shrinkage; shrinkage characteristics; process ... See more keywords
Drifting of heme-coordinating group in imidazolylmethylxanthones leading to improved selective inhibition of CYP11B1.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.07.078
Abstract: An abnormal increase in glucocorticoid levels is responsible for pathological disorders affecting different organs and systems, and the selective inhibition of appropriate steroidogenic enzymes represents a validated strategy to restore their physiological levels. In continuing… read more here.
Keywords: coordinating group; drifting heme; inhibition; cyp11b1 ... See more keywords
Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes.
Sign Up to like & getrecommendations! Published in 2023 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00686
Abstract: Adenosine deaminases acting on RNA (ADARs) are RNA editing enzymes that catalyze the hydrolytic deamination of adenosine (A) to inosine (I) in dsRNA. In humans, two catalytically active ADARs, ADAR1 and ADAR2, perform this A-to-I… read more here.
Keywords: modified rna; selective inhibition; rna; rna duplexes ... See more keywords
Selective Inhibition of PTP1B by New Anthraquinone Glycosides from Knoxia valerianoides.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of natural products"
DOI: 10.1021/acs.jnatprod.2c00879
Abstract: Protein tyrosine phosphatase 1B (PTP1B) is highly validated as a therapeutic target for type 2 diabetes. However, active site-directed PTP1B inhibitors generally suffer from poor selectivity and bioavailability. Inspired by the identification of a unique… read more here.
Keywords: selective inhibition; knoxia valerianoides; inhibition ptp1b; anthraquinone glycosides ... See more keywords
pH-Sensitive Compounds for Selective Inhibition of Acid-Producing Bacteria.
Sign Up to like & getrecommendations! Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b01089
Abstract: Stimuli-responsive compounds that provide on-site, controlled antimicrobial activity promise an effective approach to prevent infections, reducing the need for systemic antibiotics. We present a novel pH-sensitive quaternary pyridinium salt (QPS), whose antibacterial activity is boosted… read more here.
Keywords: producing bacteria; sensitive compounds; acid producing; spectroscopy ... See more keywords
Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical biology"
DOI: 10.1021/acschembio.0c00362
Abstract: The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy… read more here.
Keywords: selective inhibition; polyamine deacetylase; hdac10; polyamine ... See more keywords
Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-17920-z
Abstract: The transcription factor STAT3 is frequently activated in human solid and hematological malignancies and remains a challenging therapeutic target with no approved drugs to date. Here, we develop synthetic antibody mimetics, termed monobodies, to interfere… read more here.
Keywords: terminal; stat3; selective inhibition; coiled coil ... See more keywords
Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2077333
Abstract: Abstract In search of selective carbonic anhydrase (CA) IX inhibitors endowed with apoptotic inducing properties, we designed and synthesised two subsets of 4- and 3-(5-aryl-(4-phenylsulphonyl)-1H-1,2,3-triazol-1-yl)benzenesulphonamides. All compounds were assayed for human carbonic anhydrase (hCA) isoforms… read more here.
Keywords: inhibition; carbonic anhydrase; selective inhibition; inhibition carbonic ... See more keywords
Selective inhibition of M5 muscarinic acetylcholine receptors attenuates cocaine self‐administration in rats
Sign Up to like & getrecommendations! Published in 2018 at "Addiction Biology"
DOI: 10.1111/adb.12567
Abstract: Cocaine use disorder (CUD) remains a debilitating health problem in the United States for which there are no Food and Drug Administration‐approved treatment options. Accumulating anatomical and electrophysiological evidence indicates that the muscarinic acetylcholine receptor… read more here.
Keywords: selective inhibition; self administration; administration; cocaine self ... See more keywords