DNA lesions correlate with lymphocyte function after selective internal radiotherapy
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Immunology, Immunotherapy"
DOI: 10.1007/s00262-019-02323-x
Abstract: In patients with non-resectable hepatic malignancies selective internal radiotherapy (SIRT) with yttrium-90 is an effective therapy. However, previous data indicate that SIRT leads to impaired immune function. The aim of the current study was to… read more here.
Keywords: internal radiotherapy; dna; sirt; dna lesions ... See more keywords
Selective Internal Radiation Therapy for Hepatocellular Carcinoma Across the Barcelona Clinic Liver Cancer Stages
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06245-y
Abstract: Background Hepatocellular carcinoma (HCC) is the second most common lethal cancer, and there is a need for effective therapies. Selective internal radiation therapy (SIRT) has been increasingly used, but is not supported by guidelines due… read more here.
Keywords: hepatocellular carcinoma; radiation therapy; liver; internal radiation ... See more keywords
Personalized 90Y-resin microspheres dose determination: a retrospective study on the impact of dosimetry software on the treatment of patients with selective internal radiotherapy
Sign Up to like & getrecommendations! Published in 2023 at "Nuclear Medicine Communications"
DOI: 10.1097/mnm.0000000000001673
Abstract: Introduction The calculation of resin yttrium-90 (90Y-) microspheres activity for selective internal radiotherapy (SIRT) needs to be investigated. Methods and materials Analyses using Simplicit90Y (Boston Scientific, Natick, Massachusetts, USA) dosimetry software were performed to determine… read more here.
Keywords: selective internal; dosimetry software; internal radiotherapy; dosimetry ... See more keywords
Selective internal radiation therapy for hepatocellular carcinoma: A 15‐year multicenter Australian cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastroenterology and Hepatology"
DOI: 10.1111/jgh.15986
Abstract: The exact place for selective internal radiation therapy (SIRT) in the therapeutic algorithm for hepatocellular carcinoma (HCC) is debated. There are limited data on its indications, efficacy, and safety in Australia. read more here.
Keywords: selective internal; hepatocellular carcinoma; internal radiation; radiation therapy ... See more keywords
Nivolumab after selective internal radiation therapy for the treatment of hepatocellular carcinoma: a phase 2, single-arm study
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005457
Abstract: Purpose To evaluate the safety and efficacy of selective internal radiation therapy (SIRT) in combination with a PD-1 inhibitor in patients with unresectable hepatocellular carcinoma (uHCC) and liver-only disease ineligible for chemoembolization. Patients and methods… read more here.
Keywords: hepatocellular carcinoma; selective internal; internal radiation; single arm ... See more keywords
Selective Internal Radiation Therapy with Yttrium-90 Resin Microspheres Followed by Gemcitabine plus Cisplatin for Unresectable Intrahepatic Cholangiocarcinoma: A Phase 2 Single-Arm Multicenter Clinical Trial
Sign Up to like & getrecommendations! Published in 2022 at "Liver Cancer"
DOI: 10.1159/000525489
Abstract: Introduction: This investigator-initiated clinical trial aims to study the efficacy and safety of administering selective internal radiation therapy with resin yttrium-90 microspheres (SIRT) followed by standard chemotherapy in unresectable intrahepatic cholangiocarcinoma (ICC). Methods: A phase… read more here.
Keywords: selective internal; internal radiation; unresectable intrahepatic; radiation therapy ... See more keywords
Yttrium-90 Microsphere Selective Internal Radiation Therapy–Induced Cholecystitis
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Surgical Pathology"
DOI: 10.1177/1066896919892589
Abstract: Figure 1. Photomicrographs of yttrium-90 selective internal radiation therapy–induced chronic (A) and acute cholecystitis with mucosal erosion (B) and the presence of characteristic spherical black microspheres. Mild epithelial atypia is seen (C). Intravascular (D) as… read more here.
Keywords: radiation therapy; yttrium; internal radiation; selective internal ... See more keywords
Combined Yttrium-90 microsphere selective internal radiation therapy and external beam radiotherapy in patients with hepatocellular carcinoma: From clinical aspects to dosimetry
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DOI: 10.1371/journal.pone.0190098
Abstract: Purpose Selective internal radiation therapy (SIRT) is an effective treatment strategy for unresectable hepatocellular carcinoma (HCC) patients. However, the prognoses of patients with portal vein thrombosis, extra-hepatic metastases, or residual tumors remain poor when treated… read more here.
Keywords: radiation therapy; sirt; internal radiation; selective internal ... See more keywords
A descriptive analysis of the characteristics, treatment response and prognosis of hepatic dominant solid tumors undergoing selective internal radiation therapy (SIRT)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Gastrointestinal Oncology"
DOI: 10.21037/jgo-22-122
Abstract: Background Selective internal radiotherapy is widely used for liver dominant diseases of solid tumors. However, data about sequential treatment and prognostic factors are lacking. Methods We consecutively included all 209 patients who received a selective… read more here.
Keywords: hepatocellular carcinoma; selective internal; therapy; neuroendocrine tumors ... See more keywords
Development of an MRI-Guided Approach to Selective Internal Radiation Therapy Using Holmium-166 Microspheres
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DOI: 10.3390/cancers13215462
Abstract: Simple Summary Selective internal radiation therapy (SIRT) is a treatment for patients with liver cancer that involves the injection of radioactive microspheres into the liver artery. For a successful treatment, it is important that tumours… read more here.
Keywords: radiation therapy; sirt; internal radiation; selective internal ... See more keywords
Safety and Efficacy of Ipilimumab plus Nivolumab and Sequential Selective Internal Radiation Therapy in Hepatic and Extrahepatic Metastatic Uveal Melanoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14051162
Abstract: Simple Summary Despite recent progress on the treatment of metastatic uveal melanoma (mUM), prognosis remains dismal for the majority of patients. Directed liver therapies including selective internal radiation therapy (SIRT) have been the pillar of… read more here.
Keywords: uveal melanoma; sirt; plus nivolumab; ipilimumab plus ... See more keywords