Development of Potent and Selective Janus Kinase 2/3 Directing PG-PROTACs.
Sign Up to like & getrecommendations! Published in 2022 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.1c00650
Abstract: Aberrant activation of the JAK-STAT signaling pathway has been implicated in the pathogenesis of a range of hematological malignancies and autoimmune disorders. Here we describe the design, synthesis, and characterization of JAK2/3 PROTACs utilizing a… read more here.
Keywords: protacs; kinase directing; selective janus; development potent ... See more keywords