Carbohydrate Analogue Microarrays for Identification of Lectin‐Selective Ligands
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700091
Abstract: Fifty‐five mono‐ and disaccharide analogues were prepared and used for the construction of microarrays to uncover lectin‐selective ligands. The microarray study showed that two disaccharide analogues, 28′ and 44′, selectively bind to Solanum tuberosum lectin… read more here.
Keywords: lectin selective; analogue microarrays; selective ligands; carbohydrate analogue ... See more keywords
8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104033
Abstract: A library of 34 novel compounds based on a xanthine scaffold was explored in biological studies for interaction with adenosine receptors (ARs). Structural modifications of the xanthine core were introduced in the 8-position (benzylamino and… read more here.
Keywords: scaffold variations; variations selective; selective ligands; benzylaminoxanthine scaffold ... See more keywords
Naphthalene Diimides as Multimodal G-Quadruplex-Selective Ligands
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24030426
Abstract: G-quadruplexes are four-stranded nucleic acids structures that can form in guanine-rich sequences. Following the observation that G-quadruplexes are particularly abundant in genomic regions related to cancer, such as telomeres and oncogenes promoters, several G-quadruplex-binding molecules… read more here.
Keywords: diimides multimodal; selective ligands; multimodal quadruplex; naphthalene diimides ... See more keywords
Synthesis of Novel 2,9-Disubstituted-6-morpholino Purine Derivatives Assisted by Virtual Screening and Modelling of Class I PI3K Isoforms
Sign Up to like & getrecommendations! Published in 2023 at "Polymers"
DOI: 10.3390/polym15071703
Abstract: The phosphatidylinositol-3 kinase (PI3K) pathway is one of the most frequently activated pathogenic signalling cascades in a wide variety of cancers. In the last 15 years, there has been an increase in the search for… read more here.
Keywords: pi3k; virtual screening; class; selective ligands ... See more keywords