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Selective Macrocyclic Inhibitors of DYRK1A/B.

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2 Published in 2022 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.1c00630

Abstract: Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A) is a therapeutic target of interest due to the roles it plays in both neurological diseases and cancer. We present the development of the first macrocyclic inhibitors of DYRK1A.… read more here.

Keywords: cell; inhibitors dyrk1a; chemistry; selective macrocyclic ... See more keywords