Development of Isopropyl-Tailed Chalcones as a New Class of Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disorder
Sign Up to like & getrecommendations! Published in 2023 at "ACS Omega"
DOI: 10.1021/acsomega.2c07694
Abstract: Thirteen isopropyl chalcones (CA1–CA13) were synthesized and evaluated for their inhibitory activity against monoamine oxidase (MAO). All compounds inhibited MAO-B more effectively than MAO-A. Compound CA4 most potently inhibited MAO-B with an IC50 value of… read more here.
Keywords: mao; isopropyl; ca4; treatment parkinson ... See more keywords
Structural exploration of selected C6 and C7-substituted coumarin isomers as selective MAO-B inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2022.2033643
Abstract: Abstract Monoamine Oxidase B is considered a successful target for developing antiparkinsonian drugs. Due to the side effects of current MAO-B inhibitors, there’s an urgent need for novel potent and highly selective MAO-B inhibitors. A… read more here.
Keywords: mao; substituted coumarin; mao inhibitors; coumarin isomers ... See more keywords
Novel Series of Dual NRF2 Inducers and Selective MAO-B Inhibitors for the Treatment of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11020247
Abstract: Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease. It is characterized by a complex network of physiopathological events where oxidative stress plays a central role among other factors such as neuroinflammation and protein… read more here.
Keywords: disease; parkinson disease; inducers selective; dual nrf2 ... See more keywords
Development of a Novel Class of Pyridazinone Derivatives as Selective MAO-B Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27123801
Abstract: Sixteen compounds (TR1–TR16) were synthesized and evaluated for their inhibitory activities against monoamine oxidase A and B (MAOs). Most of the derivatives showed potent and highly selective MAO-B inhibition. Compound TR16 was the most potent… read more here.
Keywords: mao inhibitors; mao; tr2 tr16; selective mao ... See more keywords