Discovery of 2(1H)-Quinoxalinone Derivatives as Potent and Selective MAT2A Inhibitors for the Treatment of MTAP-Deficient Cancers.
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DOI: 10.1021/acs.jmedchem.4c01635
Abstract: Methionine adenosyltransferase 2A (MAT2A) has emerged as a synthetic lethal drug target in cancers bearing homozygous methylthioadenosine phosphorylase (MTAP) gene deletion. Despite the remarkable progress in the discovery and development of MAT2A inhibitors, current understanding… read more here.
Keywords: mat2a; selective mat2a; mat2a inhibitors; mtap deficient ... See more keywords