Discovery of MAP855, an Efficacious and Selective MEK1/2 Inhibitor with an ATP-Competitive Mode of Action.
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DOI: 10.1021/acs.jmedchem.1c02192
Abstract: Mutations in MEK1/2 have been described as a resistance mechanism to BRAF/MEK inhibitor treatment. We report the discovery of a novel ATP-competitive MEK1/2 inhibitor with efficacy in wildtype (WT) and mutant MEK12 models. Starting from… read more here.
Keywords: selective mek1; inhibitor; mek1 inhibitor; atp competitive ... See more keywords