Liver‐Selective MMP‐9 Inhibition in the Rat Eliminates Ischemia‐Reperfusion Injury and Accelerates Liver Regeneration
Sign Up to like & getrecommendations! Published in 2019 at "Hepatology"
DOI: 10.1002/hep.30169
Abstract: Recruitment of liver sinusoidal endothelial cell progenitor cells (sprocs) from the bone marrow by vascular endothelial growth factor‐stromal cell‐derived factor‐1 (VEGF‐sdf‐1) signaling promotes recovery from injury and drives liver regeneration. Matrix metalloproteinases (MMPs) can proteolytically… read more here.
Keywords: selective mmp; liver regeneration; liver selective; mmp inhibition ... See more keywords
Recent opportunities in matrix metalloproteinase inhibitor drug design for cancer
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2018.1398732
Abstract: ABSTRACT Introduction: The overexpression of matrix metalloproteinase (MMP) plays an important role in the context of tumor invasion and metastasis, and MMP-2 has been characterized as the most validated target for cancer. Therefore, it is… read more here.
Keywords: matrix metalloproteinase; selective mmp; mmp; drug ... See more keywords