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   Articles with "selective modulation" as a keyword



Selective Modulation of Trk Receptors by Cyclo-Organopeptides

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recommendations! Published in 2025 at "ACS Chemical Neuroscience"

DOI: 10.1021/acschemneuro.4c00833

Abstract: Neurotrophins (NTs, including NGF, BDNF, NT-4, and NT-3) are extracellular cytokines which modulate the survival and growth of cells expressing tropomyosin receptor kinases (Trks) A–C. Cells which express Trks include many neural tissues. For instance,… read more here.

Keywords: trk; cyclo organopeptides; selective modulation; modulation trk ... See more keywords

Selective Modulation of the GluN2B/C/D Containing N‑Methyl‑d‑Aspartate Receptors: A New Frontier in Targeted Neurotherapeutics.

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recommendations! Published in 2025 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.5c00365

Abstract: N-methyl-d-aspartate receptors (NMDARs) are a class of ionotropic glutamate receptors that mediate synaptic plasticity and excitatory neurotransmission throughout the central nervous system (CNS). Dysregulation of NMDAR function has been implicated in multiple neurological disorders such… read more here.

Keywords: selective modulation; aspartate receptors; methyl aspartate; modulation glun2b ... See more keywords

Selective modulation of epileptic tissue by an adenosine A3 receptor-activating drug

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recommendations! Published in 2024 at "British journal of pharmacology"

DOI: 10.1111/bph.17319

Abstract: Adenosine, through the A1 receptor (A1R), is an endogenous anticonvulsant. The development of adenosine receptor agonists as antiseizure medications has been hampered by their cardiac side effects. A moderately A1R‐selective agonist, MRS5474, has been reported… read more here.

Keywords: adenosine; selective modulation; adenosine receptor; drug ... See more keywords
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Selective Modulation of Activated Protein C Activities by a Non-Active Site Targeting Nanobody Library.

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recommendations! Published in 2023 at "Blood advances"

DOI: 10.1182/bloodadvances.2022008740

Abstract: Activated protein C (APC) is a pleiotropic coagulation protease with anticoagulant, anti-inflammatory, and cytoprotective activities. Selective modulation of these APC activities contributes to our understanding of the regulation of these physiological mechanisms and permits the… read more here.

Keywords: activated protein; modulation; selective modulation; active site ... See more keywords