Development of selective mono or dual PROTAC degrader probe of CDK isoforms.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111952
Abstract: Cyclin-dependent kinase (CDK) family members are promising molecular targets in discovering potent inhibitors in disease settings, they function differentially. CDK2, CDK4 and CDK6, directly regulate the cell cycle, while CDK9 primarily modulates the transcription regulation.… read more here.
Keywords: degrader; development selective; protac; selective mono ... See more keywords
Selective Mono- and Diamination of 2,6-Dibromopyridine for the Synthesis of Diaminated Proligands
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.5c04396
Abstract: Selective mono- or diaminations of 2,6-dibromopyridine were performed using microwave irradiation with water as solvent in 2–2.5 h. The only significant difference between the syntheses was the inclusion of K2CO3 as base and CuI/DMPAO catalyst… read more here.
Keywords: diaminated proligands; mono diamination; selective mono; diamination dibromopyridine ... See more keywords