Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulation
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DOI: 10.1101/2022.06.28.498039
Abstract: mTORC1 regulates cell growth and catabolism in response to fluctuations in nutrients through phosphorylation of key substrates. The tumor suppressor FLCN is a RagC GTPase activating protein (GAP) that regulates mTORC1 phosphorylation of TFEB, controlling… read more here.
Keywords: flcn; flcn ragc; selective mtorc1; mtorc1 ... See more keywords