A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease
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DOI: 10.1016/j.cell.2018.03.005
Abstract: Huntington's disease (HD) is characterized by preferential loss of the medium spiny neurons in the striatum. Using CRISPR/Cas9 and somatic nuclear transfer technology, we established a knockin (KI) pig model of HD that endogenously expresses… read more here.
Keywords: selective neurodegeneration; huntington disease; pig model; knockin pig ... See more keywords