Selective Penicillamine Substitution Enables Development of a Potent Analgesic Peptide that Acts through a Non-Opioid-Based Mechanism.
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DOI: 10.1021/acs.jmedchem.1c00512
Abstract: Venom-derived compounds are of broad interest in neuropharmacology and drug development. α-Conotoxins are small disulfide-containing peptides from Conus snails that target nicotinic acetylcholine receptors (nAChRs) and are in clinical development for non-opioid-based treatment of intractable… read more here.
Keywords: selective penicillamine; penicillamine substitution; opioid based; development ... See more keywords