Abstract 4998: Selective PLK4 inhibition demonstrates synthetic lethality in TRIM37 amplified neuroblastoma and breast cancer models while less selective inhibitors do not
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DOI: 10.1158/1538-7445.am2023-4998
Abstract: Amplification and copy number gains of the 17q23 amplicon are common in breast cancer and neuroblastoma and have been associated with early relapse and poor prognosis (Ganesan et al 2012; Takita et al. 2017). A… read more here.
Keywords: inhibition; less selective; plk4; trim37 ... See more keywords