Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases
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DOI: 10.1021/acs.jmedchem.0c00499
Abstract: Visceral leishmaniasis is responsible for up to 30,000 deaths every year. Current treatments have shortcomings that include toxicity and variable efficacy across endemic regions. Previously, we reported the discovery of GNF6702, a selective inhibitor of… read more here.
Keywords: proteasome inhibitor; inhibitor; proteasome; kinetoplastid selective ... See more keywords
Epoxomicin, a Selective Proteasome Inhibitor, Activates AIM2 Inflammasome in Human Retinal Pigment Epithelium Cells
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DOI: 10.3390/antiox11071288
Abstract: Emerging evidence suggests that the intracellular clearance system plays a vital role in maintaining homeostasis and in regulating oxidative stress and inflammation in retinal pigment epithelium (RPE) cells. Dysfunctional proteasomes and autophagy in RPE cells… read more here.
Keywords: selective proteasome; inhibitor; proteasome inhibitor; aim2 inflammasome ... See more keywords