Synthesis and Development of Highly Selective Pyrrolo[2,3-d]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form
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DOI: 10.1021/acs.jmedchem.3c00428
Abstract: Colony-stimulating factor-1 receptor (CSF1R) is a receptor tyrosine kinase that controls the differentiation and maintenance of most tissue-resident macrophages, and the inhibition of CSF1R has been suggested as a possible therapy for a range of… read more here.
Keywords: csf1r; selective pyrrolo; synthesis development; autoinhibited form ... See more keywords