Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1).
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c00978
Abstract: Histone demethylase LSDl (KDMlA) belongs to the flavin adenine dinucleotide (FAD) dependent family of monoamine oxidases and is vital in regulation of mammalian biology. Dysregulation and overexpression of LSD1 are hallmarks of a number of… read more here.
Keywords: potent selective; discovery 90011; demethylase; selective reversible ... See more keywords
Selective and reversible modification of kinase cysteines with chlorofluoroacetamides
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DOI: 10.1038/s41589-018-0204-3
Abstract: Irreversible inhibition of disease-associated proteins with small molecules is a powerful approach for achieving increased and sustained pharmacological potency. Here, we introduce α-chlorofluoroacetamide (CFA) as a novel warhead of targeted covalent inhibitor (TCI). Despite weak… read more here.
Keywords: reversible modification; kinase; selective reversible; target ... See more keywords
Fast, sensitive, selective and reversible fluorescence monitoring of TATP in a vapor phase.
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DOI: 10.1039/c8cc08399a
Abstract: The development of sensors for the detection of triacetone triperoxide (TATP) has attracted great attention. Here, we constructed a low-cost, portable, reusable, visible paper-based fluorescent sensor for the sensitive detection of TATP via vapor sampling.… read more here.
Keywords: sensitive selective; fluorescence monitoring; selective reversible; fast sensitive ... See more keywords