Selective γ-Secretase Inhibition Is a Potential Target for Leukemias.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-rw2019-085
Abstract: Targeting γ-secretase subunit PSEN1 blocks mutant NOTCH signaling in T-ALL without severe NOTCH toxicity. read more here.
Keywords: potential target; selective secretase; inhibition potential; target leukemias ... See more keywords
Designing of Selective γ-Secretase Inhibitory Benzenesulfonamides through Comparative In Vitro and In Silico Analysis.
Sign Up to like & getrecommendations! Published in 2018 at "Current drug discovery technologies"
DOI: 10.2174/1570163814666170713103440
Abstract: BACKGROUND In Alzheimer's disease (AD), the gene mutations have been identified in the amyloid precursor protein (APP), the presenilin-1 (PS1) and -2 (PS2) genes. APP is a transmembrane protein which gets cleaved by α- and… read more here.
Keywords: designing selective; analysis; silico; selective secretase ... See more keywords