Design, synthesis and biological evaluation of pyridine derivatives as selective SHP2 inhibitors.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.103875
Abstract: SHP2 is a non-receptor protein tyrosine phosphatase encoded by the PTPN11 gene, which affects the transduction of multiple signaling pathways, including RAS-ERK, PI3K-AKT and JAK-STAT. SHP2 also plays an important role in the programmed cell… read more here.
Keywords: selective shp2; shp2; shp2 inhibitors; activity ... See more keywords