Rhodium-Catalyzed Selective C(sp2)-H Activation/Annulation of tert-Butyl Benzoyloxycarbamates with 1,3-Diynes: A One Step Access to Alkynylated Isocoumarins and Bis-Isocoumarins.
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DOI: 10.1021/acs.orglett.2c01901
Abstract: We report here a Rh(III) catalyzed regio- and stereoselective synthesis of alkynylated and bis-isocoumarin from 1,3-dialkyne. Exclusive one-pot formation of 3,3-bis-isocoumarin isomers has been achieved by eliminating several other possibilities. This is the first example… read more here.
Keywords: bis isocoumarin; selective sp2; rhodium catalyzed; sp2 activation ... See more keywords
Native Amino Group Directed Site-Selective ε-C(sp2)-H Iodination of Primary Amines.
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DOI: 10.1021/acs.orglett.2c04288
Abstract: Selective remote C-H activating amines using unmodified NH2 as a native directing group demonstrate compelling synthetic utilities. The 3-arylpropan-1-amine moiety is present in many drugs and candidates in clinical trials. Selective iodination of 3-arylpropan-1-amines on… read more here.
Keywords: native amino; sp2 iodination; selective sp2; group ... See more keywords
A Mild and Direct Site-Selective sp2 C-H Silylation of (Poly)Azines.
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DOI: 10.1021/jacs.8b12063
Abstract: A base-mediated protocol that allows for the site-selective sp2 C-H silylation of azines is described. This method is distinguished by its mild conditions, simplicity and excellent site-selective modulation for a diverse set of azines, even… read more here.
Keywords: site selective; site; sp2 silylation; selective sp2 ... See more keywords