Palladium(II)-Catalyzed Site-Selective C(sp3)-H Alkenylation of Oligopeptides.
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DOI: 10.1021/acs.orglett.4c03365
Abstract: An innovative palladium-catalyzed alkenylation of peptides and vinyl iodides has been developed. This method does not require the introduction of a directing group and uses carboxylic acid groups as endogenous directing groups. It is noteworthy… read more here.
Keywords: alkenylation; selective sp3; palladium catalyzed; site selective ... See more keywords
Modular Iminophosphorane as Hydrogen Atom Transfer Catalyst for Selective C(sp3)-H Functionalization.
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DOI: 10.1021/acs.orglett.5c03598
Abstract: Iminophosphoranes, readily accessed via the Staudinger reaction, have been developed as tunable hydrogen atom transfer catalysts that override thermodynamic C(sp3)-H bond-strength preferences. Under acridinium photoredox catalysis, selective C(sp3)-H alkylation proceeds across diverse substrates, and systematic… read more here.
Keywords: sp3; selective sp3; atom transfer; hydrogen atom ... See more keywords
PdII-Catalyzed Site-selective β- and γ-C(sp3)-H Arylation of Primary Aldehydes Controlled by Transient Directing Groups.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c13586
Abstract: Pd(II)-catalyzed site-selective β- and γ-C(sp3)-H arylation of primary aldehydes is developed by rational design of L,X-type transient directing groups (TDG). External 2-pyridone ligands are identified to be crucial for the observed reactivity. By minimizing the… read more here.
Keywords: arylation primary; selective sp3; catalyzed site; sp3 arylation ... See more keywords
Switchable electrochemical pathways for the selective C(sp3)-Ge bond formation
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DOI: 10.1038/s41467-025-62141-x
Abstract: The development of efficient and general strategies for constructing alkyl germanes is crucial due to their significant roles in various areas that impact human quality of life. Herein, we report a robust electrochemically driven method… read more here.
Keywords: alkyl; selective sp3; electrochemical pathways; alkyl germanes ... See more keywords
Pd-catalysed selective C(sp3)-H arylation and acetoxylation of alcohols.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical communications"
DOI: 10.1039/c9cc02911g
Abstract: A palladium catalyzed selective C(sp3)-H arylation and acetoxylation of alcohols using a practical bidentate auxiliary were developed. Masked alcohols were selectively arylated at the β-position with diverse aryl iodides for the first time. Moreover, an… read more here.
Keywords: sp3; acetoxylation; acetoxylation alcohols; arylation acetoxylation ... See more keywords
Electrochemical radical-mediated selective C(sp3)–S bond activation
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc05507d
Abstract: Selective C(sp3)–S bond breaking and transformation remains a particularly important, yet challenging goal in synthetic chemistry. Over the past few decades, transition metal-catalyzed cross-coupling reactions through the cleavage of C(sp3)–S bonds provided a powerful platform… read more here.
Keywords: sp3 bond; sp3; selective sp3; sp3 bonds ... See more keywords
Selective C(sp3)-H bond Aerobic Oxidation Enabled by π-Conjugated Small Molecule-Oxygen Charge Transfer State
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DOI: 10.1039/d4gc02010c
Abstract: Due to the high oxidation potential of arene and alkene, previous methods of benzylic and allylic C-H oxidation necessitated the use of strong oxidizing agents, metal catalysts, or free radical... read more here.
Keywords: selective sp3; aerobic oxidation; bond aerobic; oxidation enabled ... See more keywords
Electrochemical site-selective C(sp3)-H amination of alkyl substituted indoles and pyrroles.
Sign Up to like & getrecommendations! Published in 2025 at "Chemical communications"
DOI: 10.1039/d5cc02009c
Abstract: Precise cleavage of a C(sp3)-H bond among multi-C(sp3)-H bonds with similar properties is highly valuable yet remains challenging. Herein, we develop an electrochemical site-selective C(sp3)-H amination of C2-methyl/ethyl indoles and pyrroles, achieving moderate-to-high yields without… read more here.
Keywords: sp3; selective sp3; sp3 amination; site selective ... See more keywords
Heterogeneous Chitosan@copper Catalyzed Selective C(sp3)–H Sulfonylation of Ketone Hydrazones with Sodium Sulfinates: Direct Access to β-Ketosulfones
Sign Up to like & getrecommendations! Published in 2023 at "Catalysts"
DOI: 10.3390/catal13040726
Abstract: The exploration of inexpensive and stable heterogeneous catalysts for C–S coupling reactions remains a challenging issue. Herein, we successfully prepared a new biomass-derived copper catalyst and applied it to the selective C(sp3)–H-directed sulfonylation of ketone… read more here.
Keywords: copper; catalyst; sodium sulfinates; selective sp3 ... See more keywords