Toward the Design of Ligands Selective for the C-Terminal Domain of TEADs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00075
Abstract: The Hippo signaling pathway plays a fundamental role in the control of organ growth, cell proliferation, and stem cell characters. TEADs are the main transcriptional output regulators of the Hippo signaling pathway and bind to… read more here.
Keywords: terminal domain; selective terminal; ligands selective; design ligands ... See more keywords
Antigen-responsive fluorescent antibody probes generated by selective N-terminal modification of IgGs.
Sign Up to like & getrecommendations! Published in 2018 at "Chemical communications"
DOI: 10.1039/c8cc07827k
Abstract: Novel fluorescent antibody probes, which show antigen-dependent fluorescence responses, were developed by selective N-terminal fluorescent labeling of IgG monoclonal antibodies using a reductive alkylation. Several kinds of IgG against tag peptides and small molecules were… read more here.
Keywords: antibody probes; fluorescent; selective terminal; fluorescent antibody ... See more keywords